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Year : 2017  |  Volume : 4  |  Issue : 4  |  Page : 170-173

Assessment of subclinical derangement of cardiovascular autonomic regulation in stable asthmatic patients

1 Department of Respiratory Medicine, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana, India
2 Department of Physiology, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana, India

Correspondence Address:
Rajesh Gupta
H. No. 32/9J, Medical Campus, PGIMS, Rohtak - 124 001, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijcep.ijcep_54_17

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Background and Aim: Autonomic nervous system(ANS) is linked to asthma. The ANS controls several aspects of airway function. It was planned to assess the autonomic cardiovascular regulation in stable asthmatic patients by short-term heart rate variability(HRV) analysis. Methods: The present study was conducted in the Department of Respiratory Medicine in collaboration with the Department of Physiology, Pt. B.D.S PGIMS, Rohtak in a total of eighty subjects/patients with comparable age, sex, weight, and height. Two groups with forty subjects/patients in each were formed as follows: Group1: stable asthmatics and Group2: nonasthmatics(controls). Electrocardiography and HRV of the participants were measured using digitalized polyrite-D as per the standard protocol. Results: Frequency domain parameters showed statistically significant difference between two groups. Low frequency(LF)(nu) was(48.9±17.8vs. 53.3±16.9) significantly less(P<0.05), while high frequency(HF)(nu) significantly more(41.4±15.19vs. 38.3±1.2) in Group1 as compared to Group2. LF/HF (1.2±0.6vs. 1.39±0.78) ratio was decreased significantly(P<0.05) in Group1. Conclusion: An overall reduced HRV(sympathetic activity) and deranged sympathovagal balance with vagal dominance(decreased LF, increased HF) in stable asthmatics. Hence, HRV could serve as a potential noninvasive tool to assess autonomic cardiovascular regulation in asthmatics.

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