Pre-Treatment of Flowers Extract of Abelmoschus manihot Medicus on Ischemia/Reperfusion Renal Injury in Rats

Jin Song O; Sin Hyok Paek; Yong Su Ri; Yong Jae Kang; Yong Bok Paek; Yong Jun Kim; Kang Song Ryu; Song Chan Han

doi:10.5530/ijcep.2025.12.2.14

Jin Song O Postgraduate School, Pyongyang University of Medical Sciences, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Sin Hyok Paek Department of Traditional Koryo Medicine, Pyongyang University of Medical Sciences, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Yong Su Ri Department of Traditional Koryo Medicine, Pyongyang University of Medical Sciences, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Yong Jae Kang Department of Gastroenterology, Sinuiju College of Medical Sciences, Sinuiju, North Pyongan Province, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Yong Bok Paek Department of Pathophysiology, Kyongsong College of Medical Service, Sinuiju, North Pyongan Province, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Yong Jun Kim Department of Health Dentistry, Dental Faculty, Pyongyang University of Medical Sciences, yongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Kang Song Ryu Postgraduate School, Pyongyang University of Medical Sciences, Pyongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
Song Chan Han Department of Pathophysiology, Pyongyang University of Medical Sciences, yongyang, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.

DOI: https://doi.org/10.5530/ijcep.2025.12.2.14

Keywords: Abelmoschus manihot (Linnaeus) Medicus (Malvaceae), Ischemia/Reperfusion, Oxidative stress

Abstract

Background and Aim: The purpose of this study is to provide a basic data with the use of flowers extract of Abelmoschus manihot (Linnaeus) Medicus (Malvaceae) (AM) as a herbal agent against renal oxidative stress. Methods: Pre-treatment effect of flowers extract of AM in rat with renal Ischemia/Reperfusion (I/R) injury was investigated. Renal I/R injury in rat were induced by clamping of the left and right renal arteries for 45 min followed by 24 h of reperfusion after administration of flowers extract of AM for 30 days. The effect of flowers extract of AM was evaluated through the measurement of renal function and the relevant parameters of oxidative stress. Results: Renal I/R injury led to renal dysfunction as evidenced by higher serum BUN and creatinine along with increase in oxidative stress in renal tissues compared with Sham group. Pre- treatment of flowers extract of AM decreased serum BUN, creatinine, and renal MDA levels, and increased SOD, CAT and GSH-PX activities in the kidney. Conclusion: Collectively, these data indicated that flowers extract of AM could be used as a safe and natural antioxidant for the protection of oxidative stress in kidney.