The Impact of Musa acuminata Sap on Leptin and Adiponectin Concentration in High Fat Diet Induced Obesity on the Offspring of Wistar Rat

Ani Celestine Okafor; Polycarp Amarachi Favour; Oti Clinton Uchenna; Ejim Nnamdi Ferdinand; Nweke Luke Maduka; Ugwuagbo Valentine; Onah Emmanuel Sunday; Okeke Adaobi Pearl; Etim Bassey Nyong; Agbor Joseph Ikenna

doi:10.5530/ijcep.2024.11.3.19

Ani Celestine Okafor Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, State University of Medical and Applied Sciences, Igbo- Eno , Nsukka, Enugu State Nigeria, NIGERIA.
Polycarp Amarachi Favour Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria Enugu Campus, NIGERIA.
Oti Clinton Uchenna Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria Enugu Campus, NIGERIA.
Ejim Nnamdi Ferdinand Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, INDIA.
Nweke Luke Maduka Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria Enugu Campus, NIGERIA.
Ugwuagbo Valentine Anatomy, Faculty of Basic Medical Sciences, College of Medicine, State University of Medical and Applied Sciences, Igbo- Eno , Nsukka, Enugu State Nigeria, NIGERIA.
Onah Emmanuel Sunday Deparrment of Opthalmology, David Umahi Federal Teaching Hospital, Uburu, EbonyI State Nigeria, NIGERIA
Okeke Adaobi Pearl Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria Enugu Campus, NIGERIA.
Etim Bassey Nyong Department of Public Health, Faculty of Health Sciences, Taraba State University, Jalingo, Taraba State Nigeria, NIGERIA.
Agbor Joseph Ikenna Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria Enugu Campus, NIGERIA.

DOI: https://doi.org/10.5530/ijcep.2024.11.3.19

Keywords: Adiponectin, High-fat diet, Leptin, Musa acuminate, Obesity, Wistar rats

Abstract

Background and Aim: The prevalence of obesity and its associated metabolic disorders is a significant global health challenge, necessitating the exploration of novel therapeutic strategies to improve the health and wellbeing of individuals battling this ill health. This study investigated the impact of Musa acuminata sap (MAS) on serum leptin and adiponectin concentration and overall body weight of Wistar rats subjected to High Fat Diet (HFD) induced obesity and also on the offspring of the experimental group. Methods: A total of 50 Wistar rats were procured of which group A-served as the normal control and received rats chow and water ad libitum, Group B=Obesed+pregnant untreated and were all fed with normal rat chow and water ad libitium. Groups C, D, E, F, G and H of five rats each were obese and were selected and divided into the five groups viz; Group C- obese without treatment, Group D-obese+100 mg/kg MAS, Group E-obese+200 mg/kg of MAS, Group F-obese+pregnant+100 mg/kg of MAS, Group G-obese+pregnant+200 mg/kg of MAS and Group H-obese+pregnant+1.2 mg/kg of Xenical IP. Induction of pregnancy was carried out and varying doses of MAS and standard drug Xenical IP was administered for another period of 4 weeks and their effects were analyzed. Data for body weights, concentration of serum leptin and adiponectin were collected and analyzed. Post-partum, body weight and length of offspring were also measured and recorded. Data from experimental and control groups were evaluated and compared to determine differences in the various groups. Results: Musa acuminata sap had statistical p<0.05 significant decrease in body weight and serum leptin concentration while increasing serum adiponectin concentration compared to the normal control. Conclusion: These findings suggest that Musa acuminata sap possesses potential anti-obesity properties possibly through modulation the of leptin and adiponectin concentration, highlighting it as a possible therapeutic agent for the management of obesity and metabolic disorders. Therefore, Public awareness should also be made and encouraged to help people prevent and manage obesity.