Effect of Intraperitoneal Injection of Aspirin on Vascular Calcification in a Rat Model

You Jong Go; Yong Il Ri; Song Chan Han; Un Byol Jong; Myong Hui Kim

doi:10.5530/ijcep.2024.11.3.18

You Jong Go Pyongyang University of Medical Sciences, Pyongyang, NORTH KOREA
Yong Il Ri Pyongyang University of Medical Sciences, Pyongyang, NORTH KOREA
Song Chan Han Pyongyang University of Medical Sciences, Pyongyang, NORTH KOREA
Un Byol Jong Pyongyang University of Medical Sciences, Pyongyang, NORTH KOREA
Myong Hui Kim Pyongyang University of Medical Sciences, Pyongyang, NORTH KOREA

DOI: https://doi.org/10.5530/ijcep.2024.11.3.18

Keywords: Aspirin injection, Diabetes, Experimental model, Vascular calcification, Warfarin

Abstract

Background and Aim: Aspirin (ASA) is crucial in safeguarding patients at high risk for cardiovascular events by reducing ischemic occurrences. Its protective effects are due to trans-acetylation, which involves a reaction between ASA and the amino groups found in lysine and N-terminal residues. To date, there have been no studies on aspirin injection in arterial calcification. The aim was to confirm by experiments that acetylated aspirin injection can significantly alleviate arterial calcification. Methods: The rat’s model of diabetic arterial calcification induced by diabetes+WVK (Warfarin and Vitamin K) and the effect of aspirin injection was evaluated through the measurement of vascular calcification in aorta, smaller arteries. Results: Rats that received aspirin injections (60 and 90 mg/kg) for a week showed a significant reduction in calcification in both the aorta and peripheral arteries. Conclusion: These results suggested that aspirin injection may be a useful in treatment of vascular calcification.