NLR and vaccine immunity Neutrophil to Lymphocyte Ratio an Indicator of Hepatitis B Vaccine Response in Haemodialysis Patients

NLR and vaccine immunity

Abstract

Neutrophil to Lymphocyte Ratio (NLR) is a new, cheap and sensitive and predictable test in many diseases especially if it be high but the lower level is also important. This study tries to show importance of NLR and immunity level following hepatitis B vaccination. 100 cases with ESRD received last dose of hepatitis b vaccine and their Complete blood count and NLR was recorded, their immunity level were assayed after six months, the relation of immunity response and NLR were analysed, NLR >3.58 is high and <0.8 is low. Data processed in SPSS 19 by Chi square and Mann Whitney U tests were used and p<0.05 was significant. 100 cases entered to study aged (year) between 27 and 86, mean±SD 62±14 years, NLR median (Minimum, Maximum) was 2.5 (0.56, 8.8), mean±SD of NLR was 2.7± 1.3, low NLR was seen in 4% and high in 16% of cases, there is not any relation between high NLR >3.58 and antibody response (titer above 10 IU/L) X2 (1,93) p 0.7, there is strong relation between Low NLR<0.8 and non-response to antibody X2 (1,80) p 0.03, likelihood ratio:6.9. Low NLR increases the risk of non-response to hepatitis B vaccination the lowest cut off level is less than 0.8 in our study. It is warranted to retest this theory on very high NLR and larger sample with regard that it was the first study in this field.