Effects of Acute Aluminium Exposure on Liver Cytoarchitecture of Adolescent Female Wistar Rats

Hare Krishna; Tripti Sharma; Priyanka Tanwar; Surajit Ghatak; Prasunpriya Nayak

doi:10.5530/ijcep.2021.8.4.36

Hare Krishna Department of Anatomy, All India Institute of Medical Sciences, Jodhpur, Rajasthan, INDIA.
Tripti Sharma Department of Physiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, INDIA.
Priyanka Tanwar Department of Physiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, INDIA.
Surajit Ghatak Department of Anatomy, All India Institute of Medical Sciences, Jodhpur, Rajasthan, INDIA.
Prasunpriya Nayak Department of Physiology, All India Institute of Medical Sciences, Jodhpur 342005, Rajasthan, INDIA.

DOI: https://doi.org/10.5530/ijcep.2021.8.4.36

Keywords: Aluminium, Liver, Hepatotoxicity, Adolescent, Acute exposure.

Abstract

Background and Aim: Exposure to aluminium is unavoidable, but there is no useful function of aluminium in our body. There are several reports demonstrating hepatotoxicity of aluminium. The current investigation was planned to evaluate the effects of acute exposure of aluminium to adolescent female Wistar rats. Methods: Adolescent female Wistar rats were intraperitoneally exposed to AlCl₃ at a dose of 5 and 10 mg/Kg bw for 2 weeks. Results: There was no statistically significant change in the growth and size of livers of the exposed animals. However, the current doses of aluminium exposures caused significant reductions in total number of hepatocytes and significant rise in hepatocytes with cytosolic vacuolation. In addition, there were certain other histopathologic changes in the cytoarchitecture of hepatic tissues. Conclusion: In summary, this is the first report showing degenerative changes in liver by low dose of aluminium exposure for 2 weeks in adolescent female rats. This could be used as real-life hepatotoxic model in adolescent rats.