Neuroimmunomodulation in obesity

Dr. Gopal Krushna Pal; Venugopal Lalitha; Pravati Pal; Murugaiyan Sathish Babu

Dr. Gopal Krushna Pal Department of Physiology, Jawaharlal Institute of Post‑graduate Medical Education and Research, Puducherry ‑ 605 006, India.
Venugopal Lalitha Department of Physiology, Indira Gandhi Medical College and Research Institute, Puducherry, India.
Pravati Pal Department of Physiology, Jawaharlal Institute of Post‑graduate Medical Education and Research, Puducherry, India.
Murugaiyan Sathish Babu Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Puducherry, India

Keywords: Immunomodulation, inflammation, neuroendocrine, obesity

Abstract

Obesity is the major risk factor for many chronic diseases such as diabetes, hypertension, cardiovascular diseases, and cancer. Obesity has a negative impact on the immune systems. Obesity is associated with chronic low‑grade inflammation and altered immune functions. The regulation of body weight is by the interplay of many neuronal circuitries in the brain that control the food intake and energy expenditure. There is a link between the central nervous system (CNS) and immune system. Therefore, in the present review article, we have discussed the immunomodulation in obesity and its interactions with the CNS.