Effects of Combined Action of Valproate and Ginkgo biloba on Cognitive Function in Penicillin-Induced Developmental Epilepsy of Rat

Abstract

Background and Aim: The aim of this study is to demonstrate the effect of combined action of Valproate and Ginkgo biloba on cognitive function in penicillin-induced developmental epilepsy of rat. Methods: Penicillin-induced developmental epilepsy in adolescence rat was established by intraperitoneal injection of penicillin diluted in saline as previously reported. Rats were assigned to 3 groups: Control group (CG), Penicillin-induced seizures group (MG) and Combination group of Valproate and Ginkgo biloba (V+G). The effect of combination of Valproate and Ginkgo biloba was evaluated through the test of water maze. Results: The present study demonstrated that the combination of Valproate and Ginkgo biloba improved cognitive dysfunction and resulted in higher therapeutic efficacy. Conclusion: Our data provide that combination of Valproate and Ginkgo biloba may be useful for treatment of developmental Epilepsy.