Exogenous Nitric Oxide Plays Important Roles in Wound Healing and has an Antibacterial Effect

International Journal of Clinical and Experimental Physiology

  • Nam-Il Ji1Department of Dermatology, Hospital of Chongjin College of Medical Sciences, Chongjin City, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Kwang-Ho Choe1Department of Dermatology, Hospital of Chongjin College of Medical Sciences, Chongjin City, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Ju-Song Choe2Department of Dermatology, Hospital of Pyongyang University of Medical Sciences, Pyongyang City, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Sol-Hui Pak2Department of Dermatology, Hospital of Pyongyang University of Medical Sciences, Pyongyang City, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Chol Kim1Department of Dermatology, Hospital of Chongjin College of Medical Sciences, Chongjin City, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.
  • Yong-Sim Kwon3Department of Plastic Surgery, Hospital of Pyongyang University of Medical Sciences, DEMOCRATIC PEOPLE’S REPUBLIC OF KOREA.

Volume 12 Issue 4 Pages 127-130

DOI: 10.5530/ijcep.2025.12.4.27

Abstract

Background and Aim: While air plasma has been widely used in biomedical or clinical applications, nitric oxide produced with plasma is thought to play important roles and be significant in biological activities. Our aim is to elucidate the role of exogenous nitric oxide in wound healing and antibacterial effect. Methods: 140 Wistar rats weighing 180 to 230 g were used. They were injured and irradiated by NO-containing plasma. Results: Wound healing was promoted in case of NO-containing plasma therapy. Conclusion: Exogenous nitric oxide prompts wound healing and has an antibacterial effect.

Keywords

  • Nitric oxide
  • Exogenous nitric oxide
  • Wound healing
  • Antibacterial effect
  • Plasma therapy
  • Experimental model

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    PUBLISHED: 2025-04-18

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