TY - JOUR AU - Hwang Won Gang AU - Han Song Chan AU - Kim Jang Mi PY - 2023/05/09 Y2 - 2024/03/29 TI - Impact of Oral Contraceptive on Induction of Ischemic Stroke in Female Rats JF - International Journal of Clinical and Experimental Physiology JA - ijcep VL - 9 IS - 4 SE - Original Article DO - 10.5530/ijcep.2022.9.4.33 UR - https://www.ijcep.org/index.php/ijcep/article/view/689 AB - Background and Aim: There are evidences for role of oral contraceptives on the induction of ischemic stroke in clinical practice, but pathophysiological mechanism underlying these close relationships remains unknown. Furthermore, the impact of oral contraceptive on induction of ischemic stroke in female rats has not been previously studied. This study investigated the induction of ischemic stroke by dose-dependent oral contraceptive in rats. Methods: Wistar 30 rats were randomly chosen and divided into three groups: High dose group-1 received daily oral contraceptive (OC), ethinylestradiol (20 mg/kg orally for 16 days) and low dose group-2 (5 mg/kg orally for 16 days) while control group received daily oral saline. The number of neurons per slice in the CA1 hippocampal region and the changes of neurological score as behavioral testing were measured in each group. Results: We demonstrated the number of neurons per slice in the CA1 hippocampal region in both high and low dose of oral contraceptive decreased in female rats, in particular, in high group was significantly decreased compared with control group. In addition, a neurological deficit was evident in dose-dependent of oral contraceptive. Further studies are needed to confirm the pathological mechanisms by oral contraceptives but our data provide that oral contraceptive, ethinylestradiol may induce ischemic stroke in dose-dependent. ER -