• Users Online: 461
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2017  |  Volume : 4  |  Issue : 2  |  Page : 82-86

Association of prehypertension status with sympathovagal imbalance in young first-degree relatives of Type 2 diabetics in Indian population is linked to body mass index


1 Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
2 Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Correspondence Address:
Gopal Krushna Pal
Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Karaikal, Puducherry - 605 006
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijcep.ijcep_34_17

Rights and Permissions

Background and Aim: As reports indicate that autonomic imbalance and hypertension in first-degree relatives (FDR) of type 2 diabetics predispose them to cardiovascular (CV) risks, in the present study, we have assessed contribution of body mass index (BMI) to sympathovagal imbalance (SVI) and prehypertension status in these patients. Methods: BMI, basal heart rate (BHR), blood pressure (BP), prehypertension status, rate pressure product (RPP), and spectral indices of heart rate variability (HRV) were reordered and analyzed in FDR of type 2 diabetics (Study group, n = 63) and in individuals with no family history of diabetes (Control group, n = 87). Results: BMI and low-frequency-high-frequency (LF-HF), the ratio of LF to HF power (LF-HF ratio) of HRV, a sensitive marker of SVI was significantly increased (P < 0.001) in the study group compared to control group. The SVI in the study group was due to concomitant sympathetic activation (increased LF) and vagal inhibition (decreased HF). In the study group, BMI was significantly correlated with LF-HF ratio, BHR, BP, and RPP. Multiple regression analysis demonstrated an independent contribution of BMI to prehypertension status and bivariate logistic regression revealed significant prediction of prehypertension status by LF-HF and BMI in the study group. Conclusion: BMI is more in FDR of type 2 diabetics and SVI in the form of increased sympathetic and decreased parasympathetic activity is present in them. Increased resting heart rate, elevated prehypertension status, decreased HRV, and increased RPP in these participants make them vulnerable to CV risks. BMI in these participants could be the link between SVI, prehypertension, and CV risks.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed329    
    Printed12    
    Emailed0    
    PDF Downloaded61    
    Comments [Add]    

Recommend this journal