• Users Online: 252
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 1  |  Issue : 2  |  Page : 142-147

Event related evoked potentials in pregnancies complicated with preeclampsia


1 Department of Physiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India
2 Department of Physiology, ESI Dental College, New Delhi, India
3 Department of Physiology, Maulana Azad Medical College, New Delhi, India
4 Department of Obstetrics and Gynaecology, Lok Nayak Hospital, New Delhi, India

Correspondence Address:
Asha Yadav
53 D, Pocket J and K, Dilshad Garden, New Delhi 110 095
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2348-8093.137413

Rights and Permissions

Background and Aim: Preeclampsia is the most significant cause of neurocognitive disturbances in pregnancy. These symptoms may persist for many years after the index pregnancy even if the somatic symptoms of preeclampsia disappear. In the present study, we have assessed the early cognitive changes in preeclamptic females with the help of event related evoked potentials (EREPs). Methods: EREPs were recorded in 20 diagnosed patients of preeclampsia with the help of computerized evoked potential recorder using the standard auditory 'oddball' paradigm. An equal number of age and gestation matched healthy pregnant females served as controls. The latencies and amplitudes of different waves of EREPs in both the groups were analyzed by using student's unpaired T-test. Correlation of P3 (main tool for cognition assessment) with blood pressure parameters was done by using Pearson's correlation coefficient. Results: Latencies of waves N 2 and P 3 from frontal, central and parietal ( FzA 1 A 2 , CzA 1 A 2, and PzA 1 A 2 , respectively) were found to be significantly delayed in preeclamptic females when compared to their normal contemporizes. Neither latencies nor amplitudes of P 3 were found to be significantly correlated with systolic blood pressure, diastolic blood pressure, or mean arterial pressure. Conclusion: Our results conclude that there are cognitive disturbances during the preeclamptic pregnancy. Prolonged latencies of EREP waves indicate that the cognitive functions such as information discrimination and reaction take longer time in preeclamptic patients when compared to their normal counterparts. This could be an electrophysiological manifestation of future memory loss in patients having preeclampsia.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2995    
    Printed55    
    Emailed2    
    PDF Downloaded165    
    Comments [Add]    

Recommend this journal